Various modifications of pyrrolidine (123-75-1) are present in both natural and synthetic drugs, as well as in drug candidates. The pyrrolidine ring structure is a common feature in numerous natural alkaloids and serves as the foundational structure for racetam compounds. Additionally, the amino acids proline and hydroxyproline can be considered structural derivatives of pyrrolidine.
Pyrrolidine CAS 123-75-1 Technical Information
Tetrahydro pyrrole;Pyrrolidine [UN1922] [Flammable liquid];Pyrrole, tetrahydro-;Tetramethyleneimine;Pyrrolidinepyrrolidine;Azolan;EINECS 204-648-7;1-Azacyclopentane;T5MTJ;Tetrahydropyrrole,Tetramethyleneimine;MFCD00005249;Pyrrolidine;Tetrahydropyrrole
87-88 °C/760 mmHg (lit.)
0.852 g/mL at 25 °C (lit.)
Colorless transparent liquid
Industrially, pyrrolidine is prepared by subjecting 1,4-butanediol and ammonia to a reaction at a temperature range of 165–200 °C and a pressure of 17–21 MPa. This reaction occurs in the presence of a cobalt- and nickel oxide catalyst, which is supported on alumina.
Pyrrolidine synthesis Wikipedia
In nature, pyrrolidine is a natural product found in various organisms, such as Piper nigrum and Vitis vinifera, with relevant data available on its presence.
Physically, pyrrolidine appears as a colorless to pale yellow liquid with an odor reminiscent of ammonia. Its vapors are heavier than air, and the combustion of pyrrolidine produces toxic oxides of nitrogen.
Chemically, pyrrolidine is characterized as a cyclic amine with a five-membered ring consisting of four carbon atoms and one nitrogen atom. It serves as the parent compound of the pyrrolidine family and is classified as a saturated organic heteromonocyclic parent, belonging to both pyrrolidines and azacycloalkanes. Furthermore, it acts as the conjugate base of a pyrrolidinium ion.
Pyrrolidine (CAS 123-75-1) finds numerous applications across a range of industries, including:
Chemical Synthesis: Pyrrolidine serves as an integral building block in the creation of pharmaceuticals, agrochemicals, and specialty chemicals. With its unique chemical structure, pyrrolidine is an invaluable intermediate in creating complex molecules.
Polymer and plastic industries: Pyrrolidine plays an integral part in the polymer and plastic industries, contributing to their production by increasing properties and performance in applications like coatings and adhesives.
Corrosion Inhibitors: Pyrrolidine can be found in corrosion inhibitors used to protect metal surfaces from deterioration in industrial settings, as well as solvent and reagent applications in various chemical processes and lab experiments.
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