Description
PyBOP Technical Information:
Chemical Name | Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate |
CAS Number | 128625-52-5 |
Common Name | PyBOP |
Formula | C18H28F6N6OP2 |
Melting point | 154-156 °C (dec.)(lit.) |
Density | 1.438 at 20℃ |
Vapor pressure | 0-0Pa at 20-50℃ |
Storage temp. | 2-8°C |
Solubility | methanol: 25 mg/mL, clear |
Form | Fine Crystalline Powder |
Color | White to off-white |
Sensitive | Moisture Sensitive |
InChIKey | BYCLGHOAELJLOF-UHFFFAOYSA-M |
PyBOP (benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent employed in solid phase peptide synthesis, serving as an alternative to the BOP reagent. Due to its efficacy and low racemization rates, PyBOP is extensively utilized in peptide chemistry to facilitate amide bond formation. Its action induces a nucleophilic attack by amines on carboxylic acids, which initiates peptide bond formation. It has advantages over some other coupling reagents in terms of minimal side reactions and ease of handling.
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